Project title

Partners involved

Biomarkers of susceptibility

Correspondence between genotype, expression levels and repair phenotype with respect to oxidative damaged DNA bases and association with risk of lung cancer

1. University of Copenhagen
2. Vrije Universiteit Brussel

To investigate the relation between DNA repair phenotypic assays and cancer risk using the host-cell reactivation and the comet assays

1. Institute of Scientific Interchange, Torino
2. University of Copenhagen

Inter- and intra-laboratory comparison of genotyping methods and equipment

1. Finnish Institute of Occupational Health, Helsinki
2. Nofer Institute of Occupational Medicine, Lodz
3. Institute of Scientific Interchange, Torino
4. Genetics Research Institute & Ospedale Policlinico,  Milan
5. University of Maastricht
6. Catalan Institute of Oncology, Barcelona
7. University of Dundee Biomedical Research Centre

Analysis of genetic polymorphism and expression patterns of metabolizing enzymes as applied to environmental carcinogenesis

1 Nofer Institute of Occupational Medicine, Lodz
2. University of Mainz

Use of lymphoblastoid cell lines for the identification of at risk genotypes: validation of cell lines for the DNA repair response

1. Institute of Scientific Interchange, Torino
2. University of Copenhagen

Biomarkers of exposure, early effects & risk

Development of new/improved biomarkers of exposure or susceptibility to N-nitroso compounds and other simple alkylating agents

1. National Hellenic Research Foundation, Athens
2. University of Leicester

Improving the methodology of ³²P-postlabelling

1. Institute of Cancer Research, Sutton, UK
2. German Cancer Research Centre, Heidelberg
3. Karolinska Institute, Stockholm
4. University of Leicester
5. Josef Fodor National Center for Public Health, Budapest
6. University of Maastricht

Inter-relationships of urinary DNA lesions

1. Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz
2. University of Leicester

Towards consensus for the measurement of urinary 8-oxo-7,8-dihydro-2'deoxyguanosine

1. Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz
2. University of Leicester
3. University of Copenhagen

Detection of DNA adducts by capillary electrophoresis and laser induced fluorescence

1. University of Maastricht
2. Josef Fodor National Center for Public Health, Budapest

Improved postlabelling of N7-guanine adducts

Karolinska Institute, Stockholm

Inter laboratory comparison for postlabelling of bulky DNA adducts

1. Karolinska Institute, Stockholm
2. Josef Fodor National Center for Public Health, Budapest

Development of a biomarker for assessing exposure to acetaldehyde

Karolinska Institute, Stockholm

Development of methods for determination of tobacco-smoke related collagen adducts in human lung - possible biomarkers of long-term exposure

1. University of Lund
2. Josef Fodor National Center for Public Health, Budapest

DNA-adduct formation of the newly discovered carcinogenic air pollutant NBA

1. Karolinska Institute, Stockholm
2. Institute of Cancer Research, Sutton, UK

Genetic and epigenetic alterations in plasma DNA of healthy and cancers subjects as biomarkers of exposure or tumorigenesis

1. International Agency for Research on Cancer, Lyon
2. Institute of Scientific Interchange, Torino

Molecular epidemiology

Validation of NNOC-related DNA  adducts and assessment of their determinants in the general population

1. National Hellenic Research Foundation, Athens
2. Catalan Institute of Oncology, Barcelona
3. German Cancer Research Centre, Heidelberg
4. Karolinska Institute, Stockholm
5. University of Leicester
6. International Agency for Research on Cancer, Lyon
7. University of Maastricht

Effect of cigarette smoking, and association with other cigarette smoke-induced DNA damage and repair, of 0⁴-ethylthymidine in human lungs

1. German Cancer Research Centre, Heidelberg
2. Josef Fodor National Center for Public Health, Budapest

Urban air particles and cancer

Karolinska Institute, Stockholm

Relationships between exposure, biomarkers of cytogenetic effects and differential gene expression in a family study

1. University of Maastricht
2. University of Copenhagen

Risk assessment

Exposure-response relations and risk estimates in asphalt-exposed cohorts

1. Institute of Risk Assessment Sciences, Utrecht
2. International Agency for Research on Cancer, Lyon

Mechanistic approaches

Oxidative stress and cancer

Karolinska Institute, Stockholm

CYP1A1 and CYP1B1 in PAH metabolism and DNA adduct formation

1. University of Dundee Biomedical Research Centre
2. Biochemical Institute of Environmental Carcinogens Prof. Dr Gernot Grimmer Foundation

Pharmacokinetics of metabolism and metabolic activation of B[a]P and other carcinogens in different tissues of mice

1. Institute of Cancer Research, Sutton, UK
2. University of Dundee Biomedical Research Centre

Identification of benzo[a]pyrene regulated target genes - cell type specificity and dose response

1. University of Maastricht
2. University of Mainz

Investigation of gene expression changes caused by benzo[a]pyrene via genotoxic and epigenetic pathways

1. National Hellenic Research Foundation, Athens
2. University of Maastricht
3. University of Leicester
4. Institute of Cancer Research, Sutton, UK

Molecular dissection and potential cross-talk of the biological and genetic pathways affected by benzo[a]pyren (BaP) and dioxin (TCDD)

1. University of Mainz
2. National Hellenic Research Foundation, Athens
3. University of Maastricht
4. Karolinska Institute, Stockholm
5. University of Dundee
6. Vrije Universiteit Brussel
7. Biochemical Institute of Environmental Carcinogens Prof. Dr Gernot Grimmer Foundation

Nutrition

Nuclear Receptors (Nr) - Novel targets for health-promoting foods

Karolinska Institute, Stockholm

Development of methods for the assessment of selenium status in populations - feasibiility study

1. University of Lund
2. Nofer Institute of Occupational Medicine, Lodz

Short-term effects of selenium on global gene expression in humans using selenium-rich milk and different selenium supplements

1. University of Lund
2. University of Copenhagen

Induction of oxidative stress by polycyclic aromatic hydrocarbons and its modulation by food components

1. National Hellenic Research Foundation, Athens
2. German Cancer Research Centre, Heidelberg

Analysis of the interaction of peroxiredoxin 6 with glutathione S-transferase P1 by electrospray mass spectrometry

1. University of Dundee Biomedical Research Centre
2. Karolinska Institute, Stockholm

Development of an ELISA for the assay of selenoprotein P in plasma and tissues

1. University of Lund
2. Nofer Institute of Occupational Medicine, Lodz